Sunday, April 12, 2020

COVID-19: Ceylonese Response

My Comments

I have made adequate entries on this virus (not the epidemic) at this site!

Our failure to "nip in the bud" were obvious even though government doctors (not GMOA, who bum-sucks politicians) did a creditable job.

We were lucky that we were not a tourist destination for many except Chinese and Indians (that is also for commercial exploitation) after Church Bomb and Wahabis activities which Sirisena ans Ranil failed to address (includes Mahinda too, he did not suppress its activities emerging way back in 2008 fearing loss of Muslim vote).

Cash struck we relied on Chinese and allowed Visa Office for Chinese to operate without supervision.

Very stupid political action.

I have a saying, "Never trust a Chinaman" that includes SOHO in London.

The only difference between Indians (RAW and Gandhis) and Chinese is very simple.

Indians get caught lying but Chinese never get caught with the HELP of WHO with an Ethiopian heading it shamefully.

When India and Africa get affected there is no stop of it spreading like a wildfire (poor sanitation, lack of water, malnutrition, poverty and joblessness compounding).

We may have to go back to hand to mouth existence (with unbearable debts and nobody giving a free lunch- an euphemism of mine) and NM and Sirima Era of Pan Poling-Bread queues and Manioc and Batala.

History repeats itself and SLFP/SLPP (I call it Pathala Party) unlike the UNP cannot feed the masses, especially in the North!

It is like Un SuKi of Myanmar taming the Army.

Very soon we won't be able to tame the emerging army influence on politics.

Thankfully our Police Force kept them at bay! 

Above are SAD realities (only a few mentioned).

COVID-19: Ceylonese Response

Emerging Questions, Testing Times


Reproduction

Rajan Philips

It is now one month after the WHO declared Covid-19 a global pandemic. Some clarity is emerging through the viral cloud about what happened, what went wrong and what might have been done differently. It is legitimate to ask if Wuhan had to be isolated from the rest of China, why could not China have been isolated from the rest of the world. Had that twin isolation been undertaken, China would have got reconnected with the world in 67 days at most, the time it took China to end the isolation of Wuhan. In fact, China’s external isolation would have ended a lot sooner. Trade connections and supply chains would have survived an immediate isolation with minimum disruptions, and would not have been catastrophically broken as they are now. 

This is all now hindsight, but the questions to China and the WHO are not going to go away.

There is plenty of blame to go around the world for general government inertia as well as sinister political calculations. Early warnings were ignored in the US and pandemic emergency plans meticulously prepared in western countries after the SARS crisis were not even looked at this time. 
The exceptions are the few East Asian countries, perhaps Australia and New Zealand down under, and Iceland and Denmark up north. There are broader questions as well – from the direct connections between the growth of global agri-business and the release of pathogens from their harmless natural settings to hit and harm human hosts, and the diminishing global investment in the study of and preparedness for communicable diseases relative to lifestyle illnesses. But the questions and the debates will have to wait for another day until the current fight against the virus is brought under control.

There is no primeval fight or flight option. But fight and feed. Fight the virus, feed the people. That is the task of every government and it cannot get more basic for any government. And the task should not be made more difficult by the all too familiar lapses into never ending spats over race, region and religion. When nothing works, blame the unreliable Chinese or the ugly American. If neither works, blame the Muslims, especially in South Asia. The European Union that was created to end its recurrent internal wars is warring again over supplies and subsidies in the fight against the virus. And for the great NATO, it is business as usual. They will get paid for doing nothing as usual, or for desk-top testing of non-existent pandemic scenarios, unlike everyone else in the world.       

Oh, yes, “April is the cruelest month.” T.S. Eliot would never have imagined that the famous opening line of his melancholy poem, The Waste Land, would turn out to be a morbid prophesy not only for the country of his birth, but also for the country of his adoption. The United State of America, where Eliot was born, is now the epicentre of a global pandemic. And the United Kingdom, of which he became a citizen after renouncing his American citizenship, is faring proportionately the same, if not worse. Prime Minister Boris Johnson himself has become a prime patient of Covid-19. Mr. Johnson is reportedly recovering well, after being in intensive care unit but without needing ventilator support, and much to the relief of a Brexit-battered and virus-hit nation. In general, however, and as usually alarmingly in the US, marginalized people are faring the worst.

The number of Covid-19 cases and deaths worldwide keep rising relentlessly. There are different lights in different tunnels. Europe seems to be on the mend finally, but only through a mountain of the dead. In the US the virus is surging in one state after another, but the curve appears to be flattening in general. Africa is no longer immune as it appeared to be at the start, and the worst is yet to come both for the continent’s health and its economy. East Asia is relatively stable, including China the origin of the viral quake. South Asia is sitting somewhat precariously in the middle, with India looming as the huge known unknown. That is the current picture and also the context for ongoing decision making.

Decision Making

Decisions are now being made in three interlocking planes, the science about the virus, the public action to contain its transmission, and governmental efforts to cushion the economic fallouts. The practical side of the science about the virus is all about testing. It is the paucity of testing and the lack of sufficient knowledge about the virus that has made contact tracing and physical distancing – from simple home isolation, to centralized quarantines, to total lockdowns - the only way to break the chain of transmission and stop the viral spread.

It is the same paucity that has given rise to two, rather crude but the only available, universal metrics in the tracking of the virus and the fighting of its transmission: the number of days it takes to double the number of Covid-19 cases; and the number of tests per million population. The former helps in plotting the curve and the latter to assess the extent of the virus spread and to see if and how containment measures are working. For comparison, in the pandemic hotspots like China, Italy, Spain and the US, the number of days during which cases doubled, shrank from six to seven days at the start to three to four days during the surge.

Sufficient testing is needed to decide how and when the current isolation and distancing could be relaxed, and in what stages. Until then, there are economic fallouts to be taken care of. Unlike any of the past economic upheavals, the current shutdown is the worst supply side crisis ever, and writ large over the world like never before. While during the 2008 Great Recession, the western countries were hit hard and the peripheral economies were relatively spared, it is the global periphery that will be hit harder than the economic centres in the current showdown. Global initiatives have been either promised or called for by G20 leaders ($5-trillion), the UN ($9-trillion) and a large group of former world leaders ($5-billion) – that includes President Chandrika Kumaratunga. If any or all of them were to materialize, that would ensure a significant cashflow to peripheral countries. But how soon and how much are indeterminate, and the current beggar-thy-neighbour attitude to one another among the  western countries does not augur well for much global certainty.    

Testing delays have been universal, except again for the few East Asian countries. Even the US got tied up in regulatory knots and wasted precious time in the beginning before ramping up its testing program. The countries that are doing better in containing the virus are also doing larger number of tests than others. South Korea and Singapore are at 9,000 and 12,000 tests per million people, respectively. Australia is at 13,000 tests per million people, while Bahrain and Iceland are off the charts at 35,000 and 89,000 (multiple) tests per million. Timing is important. Germany and Italy are doing 15,000 tests per million, but they started late, especially Italy. France and England are under 5,000 tests per million, while the US and Canada are hitting close to 7,000 and 10,000 tests, respectively, but with significant regional variations.

Testing time for Sri Lanka

By all accounts, Sri Lanka has done phenomenally well in contact tracing and supervised quarantining. The record on testing, however, is nowhere near as good. Currently, the tests are reportedly limited to patients only, and about 3500 tests have been carried out so far according to recent news reports. That would place Sri Lanka at about 175 tests per million people, and in the same South Asian camp as Bangladesh at 36 tests per million (with 6,000 tests), India at 107 (145,000 tests), and Pakistan at 212 (45,000 tests). Sri Lanka has been conducting 150 to 300 tests daily, although it is said to have the capacity to go up to 1500 tests a day. At this rate, it will take just over two months to reach a reasonable target of 5000 tests per million (i.e. 100,000 tests). There have also been suggestions that the daily test rate can go up to 12,000 tests a day, but there has been no follow up regarding an aggressive testing program  

There is then the debate, including in Sri Lanka, about what tests to perform and who should be targeted for tests. The primary test type is the diagnostic laboratory PCR (Polymerase Chain Reaction) test that detects the virus and confirms infection in a person. Multiple tests are needed in some cases before infection is confirmed. In many jurisdictions, this test and confirmation are required for ‘treating’ patients, even though, as some epidemiologists and physicians have pointed out, there is no accredited therapy for Covid-19.

The WHO definition of a confirmed case as “a person with laboratory confirmation of COVID-19 infection”, gives PCR test a special imprimatur. Dr. Jayaruwan Bandara, Director of the Medical Research Institute, has called it “the gold standard test” for diagnosing Covid-19. Understandably so, and the same token entails many restrictive guidelines for carrying out the test. The lab work invariably takes time and it has taken too much time even in western countries to increase the laboratory throughput of test results.

In addition, the PCR test is not a mass surveillance test to assess the spread of infection in a community. Hence the call for a second test, the serology test, that detects the antibodies that are produced to fight the virus infection. This can be used for both diagnosis and for population surveillance that will show the number of people who have been infected, including those with minor symptoms and those who are asymptomatic. Detecting asymptomatic cases is the special advantage of the serology test, knowing that asymptomatic transmission of the coronavirus is what renders it intractable.

As against these merits of serological testing, there is conventional reluctance in (government) medical and health regulatory circles to implement a serological testing program at the early stages of an epidemic. The reluctance might be because the regulatory agencies are not prepared to apply the serology test for diagnostic purposes insofar as the test does not detect the virus or early infection. Serology tests are typically used after an epidemic to assess the levels of infection and immunity in the community to prepare for the next outbreak. This point has also been made by the Director General of Health, Dr. Anil Jasinghe, who has indicated that “PCR is the test that was used by China and South Korea, at the initial stage of Covid-19, and that tests, like blood antibody testing, were used later.” The Sri Lanka Medical Association (SLMA) has also called for expanding PCR testing instead of shifting to serology testing.

On the other hand, the GMOA, in my understanding from news reports, has been pressing for implementing a rapid (serology) test program, and to carry out tests among 45,000 or so ‘contact traces’, who are in quarantine and are yet to be tested. In between, Chair Professors of Medicine (and specialist Physicians) from six of the island’s medical faculties, in their letter to Lt. Gen. Shavendra Silva, Chairman of the Covid-19 National Task Force and Dr Anil Jasinghe, Director General of Health Services, recommending next steps, have called for increasing test capacity and to “seek advice from virologists regarding what tests are most appropriate for use in specific scenarios.”

Across the world, a Canadian epidemiologist, Prof. Dawn Bowdish of McMaster University, has said that serology tests “are absolutely the gold standard for understanding the spread of this infection.” So, if both the PCR and serology tests are gold standard tests according to medical experts, albeit for different purposes, why not use both – from a simple and practical policy standpoint, to serve both purposes in Sri Lanka, and since both are needed. That is, both to diagnose patients and to track the virus spread. New serology tests are already being used in a number of countries, each priced at $10 (Rs. 2000, less than the PCR test cost of Rs. 6000), and able to give results in 20 minutes.

One more viewpoint on the matter of testing might be of particular relevance in the Sri Lankan context, with a tradition of doctors providing exceptionally good diagnosis in spite of limited resources for laboratory testing. Prof. David Fisman, Infectious Disease Epidemiologist and Physician at the University of Toronto, has suggested that given the newness of and the lack of information on Covid-19, ‘clinical case definitions’ should be used to identify Covid-19 cases where formal testing facilities are not sufficiently available. According to Dr. Fisman, clinical definitions were used during the SARS outbreak in Canada, and at the height of the current crisis in China, CT-scans were used in diagnosing Covid-19. Dr. Fisman has also suggested that in a pandemic situation such as this, every patient admitted to a hospital should be tested for Covid-19, along with healthcare providers. Testing of inmates in prisons, and other high-density dwellings and institutions would also make sense.

At this early stage of an epidemic caused by an etiologically little-known virus, the sampling for testing is invariably not random. Optimal sampling strategies have been developed for other disease epidemics that are both time-dependent and independent, and target both the vector (virus) and the host (human) populations. For now, in the case of the coronavirus, the rather crude metric of ‘tests per million’ appears to be the only guidance everywhere. Random sampling has been reported in Iceland, but the randomness assumption there is also being contested. In the light of all this and to get to practical matters, what could be the next steps in Sri Lanka?

Next Steps and Potential Slips

There is no further need to belabour the case, which is to implement both the PCR and the serological tests as rapidly as possible and as in many numbers as possible. Sri Lanka could learn from Vietnam, which has a low testing rate, about 1,200 tests per million people (and a total of 115,000 tests), but has aggressively carried out contact tracing and targeted ring-testing among the traced contacts to break the chain of transmission. The Sri Lankan government should support medical and health professionals to devise testing programs specific to each district, based on the experience so far and district-specific infection information, and implement them aggressively. There are medical faculties practically in every province and their resources should be leveraged to maximum benefit through co-ordination with the MRI and the Director General of Health Services.

It would also be helpful if the government could set up a proper professional forum where all the medical voices and opinions could be channeled and consulted without their having to find independent media outlets to express themselves. There is some media muttering that some medical voices are closer to the political powers than others. But that is inevitable and in itself should not be much of a concern, provided the scientific independence of the MRI and the administrative independence of the Director General of Health Services are not compromised.

To strike a personal note, I have found the silence of Dr. Tissa Vitarana in all of this somewhat puzzling. As onetime Director of the MRI, he was a highly respected medical scientist and was universally liked as a person, as some UNP Doctors used to say, in spite of his affiliations to the LSSP. His age should not be a factor, because everybody who is somebody in the current Administration is old. Dr. Vitarana is the only medical scientist who is politically associated with the current Administration. He is the Governor for the North Central Province and is also on the SLPP National List for the parliamentary election. And he could be a source of experience and wisdom in linking medical-scientific thinking and political decision making.

A ramped-up testing program and informed consultations based on test results will be critical in determining the next steps in coming out of the current curfew situations in the country. The virus is not going to disappear any time soon any where in the world, until an effective therapy or a successful vaccine is found. So, there cannot be a total relaxation of the current restrictive measures. In fact, it would be prudent to expect and prepare for restrictions and relaxation to alternatingly continue for rather long periods of time. And there are good practices to follow – from Vietnam, South Korea, Singapore and Taiwan.

Singapore is currently implementing a series of “stepping up measures” to deal with a second spike in the local transmission of the virus. Singapore calls the measures a “circuit breaker”, not a lockdown or a curfew, and they are being implemented with due preparation and prior notice to avoid public confusion and transport stampedes.  The measures will initially last a period of one month, which is calculated to cover two cycles of viral incubation. Additionally, modern supermarkets and traditional ‘wet markets’ will remain open and people will be allowed shop in orderly manner while maintaining minimum physical separation. These are not difficult measures and similar measures can be easily implemented in Sri Lanka. In Colombo, and other main cities, it should not be difficult to keep markets open and designate separate days of the week for households from different areas (e.g. by streets or ward) to do their shopping.  

Overall, the government faces three challenges: containing the virus; cushioning the economic fallouts; and ensuring the survival of constitutional politics. On the first, the government deserves all the credit that has been extended to it. Hopefully, it will keep up the good work, informed by sufficient test data and appropriately adopting good practices from East Asian countries. It is too soon to pass verdict on the second challenge. Even without the virus the government was in a deep hole and the virus has made it infinitely worse. Its first responsibility is to support employees and businesses who are involuntarily locked out of work, and this goes far beyond fulfilling the already established subsidy practices.

To that end, the government should look for immediate funding opportunities anywhere and everywhere, bilateral or multilateral. It could even send Chandrika Kumaratunga and Ranil Wickremesinghe as urgent emissaries to scour the world and not to return without foreign exchange. They could be more useful to the country from the outside than from within. Of course, they cannot emplane immediately, nor is physical travel really necessary with the new virus making virtual connections the new reality. Desperate times call for desperate measures, and no one is going to lose by working together in this crisis. Hopefully, I am not jinxing the possibility of a positive outcome for the country by publicly suggesting it.

The government should also forcefully nix lamebrained ideas emanating from within its ranks. Two have surfaced so far – one on (ab)using the EPF savings as a stimulus source, and the other to bring back import substitution from the long-ago dead. Neither seems to have found any traction, and hopefully both are still born, or dead on arrival. This is not to say that there is no room for new ideas, only they should not be lamebrained.

Worldwide food scarcity has been talked about even before the arrival of the virus, and its arrival makes it all the more urgent. Sri Lanka can and must re-energize its food production, but without raising barriers. It is a fact of Sri Lankan economic history that local food production has thrived only when there was no barrier at the customs, or checkpoints at district boundaries. One can be a socialist and doesn’t have to feel shy about saying this. As for new ideas, it would be worth for some in the government and the industry to explore the possibility of retooling the island’s industrial knowhow and technology in medical glove making and the garment industry to cater to the rising global demand for hospital gowns and other Personal Protection Equipment (PPE) for frontline healthcare providers. 

The third challenge is also the government’s Achilles’ heel, and where it can slip. The success here will be marked not by the extent of the SLPP’s victory at the next parliamentary election, whenever it comes, but by the extent to which President Gotabaya Rajapaksa and his Administration abide by constitutional norms in exercising executive power. A curfew without declaring emergency, avoiding emergency rule to avoid recalling parliament, and bankrolling off the national coffers, no matter how empty, without parliamentary approvals – are all jointly and severally beyond the pale in every direction. The President has the power and the option not to do any of this. And those who advise him to the contrary are not serving the President or the country well.

The latest in this vein is the missive by Presidential Secretary, Dr. P. B. Jayasundara, to Mahinda Deshapriya, Chairman of the Election Commission. The latter was ill-advised to start a public correspondence with the President on deciding a new date to hold the now postponed parliamentary election. Dr. Jayasundara, rather than elevating the discussion, has chosen to lower it by indulging in pettifogging and seriously indefensible polemics. He has lowered the office of the President. In the midst of a generational battle against a novel pathogen, President Gotabaya Rajapaksa deserves better from his Secretary.   


Saturday, April 11, 2020

My Experience with operating Ventilators

My Experience with operating Ventilators

My Experience with operating Ventilators started with neonates and ended in geriatrics.
I am thankful I am now in geriatric age and is not working in a hospital.
i quietly moved to my original interest pathology, where I have after the fact estimation of effects.
Thankfully my senior teacher, the Professor of Pathology warned me of the limitations.
He said I know only 40% currently and at best of your work and research you will bring it up to 60% and no more.
At best 40% will be a mystery and never resolved by scientific inquiry.
My research proved he was absolutely right and I could not find an explanation for 42% (2% is probably is the margin of error of my study).
my experince in paediatric neonatolgy is that I saved life briefly for them to a long life of agony with assortment of cerebral palsy and mental deficits.
It was easy for me to give up paediatric and paediatric oncology (leukaemias).

Leaving UK was instinct driven mandatory action.

Coming to geriatric ventilation, my or our plan was to wean off within five (5) days before the patient become ventilator dependent or develop ventilator related complications.
The five days was not arbitrary but a good safety valve in my experience.

I asked permission from the patient having given the basic information of the invasive procdure well in advance.
If the patient is unable to communicate I would ask the kith and kin.

My favorite patient in New Zealand with his permission put on a ventilator for three times (that was his wish).
In between the fist and third he broke both his hips which I helped to implant artificial prosthesis with 80% mobility (with 20% help, getting out and getting into the bed).
My other favorite patient with testicular cancer and large cannon ball secondaries in the lung refused ventilation by default.
His only request was for me to be at bedside when the time comes.
I was not on call but I made him a practical Buddhist in few minutes and showed him the exit and new life at the end of the tunnel.
On return from New Zealand I continued in private practice without ventilators (even for a brief periods) for five years before coming back to Dental Hospital for research without a supervisor (no emergency care or ventilators at all).
For the last three years no medical practice and no blogging for two years and the Coronavirus incarceration has made me to blog again.
I am currently trying (Kampuchia tea excluded) to identify 20 odd medicinal plants of use in day to day life.
Ginger, vinegar and lime are the fist three followed by Aralu, Bulu and Nelli  (Weniwel Gata excluded due good vaccination program including BCG).
So I have to formalize only 14 indredients (Gypsum, Sahinda Lunu and Pulmanikkam excluded with common salt).

Mind you salt and water is the best antiseptic (absolutely without sugar) to wash ones hands.
Sugar and salt are the basic ingredient of saprophytic life forms (they assemble the rest including amino acids from these two ingredients, just as by the fungus and bacteria in Kampuchia Colony).

I will stop blogging moment the curfew is listed.

Kombucha Tea

Reproduction

Kombucha Tea

Kombucha (also tea mushroom, tea fungus, or Manchurian mushroom when referring to the culture; botanical name Medusomyces gisevii is a fermented, slightly alcoholic, lightly effervescent, sweetened black or green tea drink commonly consumed for its supposed health benefits. Sometimes the beverage is called kombucha tea to distinguish it from the culture of bacteria and yeast. Juice, spices, fruit or other flavorings are often added to enhance the taste of the beverage.
Kombucha is thought to have originated in Manchuria, China where the drink is traditionally consumed, or in Russia and Eastern Europe.
Kombucha is now homebrewed globally, and also bottled and sold commercially by various companies.
Kombucha is produced by fermenting sugared tea using a symbiotic culture of bacteria and yeast (SCOBY) commonly called a "mother" or "mushroom". The microbial populations in a SCOBY vary; the yeast component generally includes Saccharomyces cerevisiae, along with other species; the bacterial component almost always includes Gluconacetobacter xylinus to oxidize yeast-produced alcohols to acetic acid (and other acids).
Although the SCOBY is commonly called "tea fungus" or "mushroom", it is actually "a symbiotic growth of acetic acid bacteria and osmophilic yeast species in a zoogleal mat [biofilm]".
The living bacteria are said to be probiotic, one of the reasons for the popularity of the drink.
Numerous implausible health benefits have been attributed to drinking kombucha.
These include claims for treating AIDS, aging, anorexia, arthritis, atherosclerosis, cancer, constipation, and diabetes, but there is no evidence to support any of these claims.
Moreover, the beverage has caused rare cases of serious adverse effects, including fatalities, possibly arising from contamination during home preparation.
Therefore, the potential harms from drinking kombucha may outweigh the benefits, so it is not recommended for therapeutic purposes.

Common Sense and Common Law


Common Sense and Common Law

We as a nation (including tress passing on pedestrian crossings and Ambulance Drivers and Government Drivers taking politicians -and some killing the pedestrians-over speeding) DO NOT follow basic rules.

What we lack is common sense and common law, that include U.N.O, W.H.O. and emerging economic Kill Country, the mainland China (aborted abruptly and TIMELY by a small or tiny RNA polymerase virus).

1. Number one is eating all animals like civet bat and snakes.

That is violation of ALL Animal Rights to live in harmony with animal predators (not for human needs) to control the population balance.

Human can survive well on a vegetarian diet!

2. Then not stealing something that belongs to a second or third party.
The king of this is killing, the 10% dealer who supervises the distribution and divert the limited resources to the “Pathala Party” or SLPP goons.

3. Then the same Pathala Kings who rape underage Girls and Boys including some saffron clothed guys.

4. Then spreading false information (that include all religions) that one of the Chiefs trying to absolve god of all responsibilities and blaming only humans.

He forgets that there still a few guys / girls who better versed and kinder than several gods (of all religions) put together!

5. Then of course the “Majja Pama Dattana Veramani” or “Tikak Gathanam Hary” or Small Tot is OK mentality.

Fortunately this is the common denominator of Ceylonese including Chief Priests (“Dasa Mula Aristata” more powerful than Vodka) and the worlds highest per capita alcohol production (both legal and illegal) and consumption country overtaking America and Russia by many a mile.

If you look at the above it is the Pan Sil or Five Precepts' Violation, Right Left and Center.

Mind you some of my friends ask me “how to make alcohol at home” and I refer them to read Louis Pasteur and his monumental experiments on yeast, rabies and small pox.

I know a very simple method (mind you one cannot make “King Coconut Wine” in Kandy due to global warming) but won’t tell you, since I have stopped making them.

There is a substitute called “Mongolian Tea” which has three ingredients.

1.Tea
2.Sugar
3. And Mongolian Fungal Flora.

Now I do not drink tea that is 90% adulterated in Ceylon.

Sugar is expensive but I love chocolates not sugar.

The fungus flora I stop cultivating many moons ago since, if it is not kept under 100% darkness in between cultures, it results in contamination of germs of all kinds including amoebae.

 Kombucha (also tea mushroom, tea fungus, or Manchurian mushroom when referring to the culture; botanical name Medusomyces gisevii) is a fermented, slightly alcoholic, lightly effervescent, sweetened black or green tea drink commonly consumed for its supposed health benefits.
 






















Wash Your Hands—A Lot

Wash Your Hands—A Lot

We all know that washing our hands keeps germs at bay—but make sure to rinse with regular soap and water, 

Lipman says. The recent popularity of antibacterial soap has created harsher products loaded with toxins that can actually increase the risk of creating resistant bacteria. These soaps also tend to over dry and crack the skin, making the transmission of viruses that much easier. So stock up on nondrying soaps and keep them on hand throughout the season.
 My Addition
 These toxic chemicals percolate into water and kill fish (gills are affected) and also friendly microorganisms.
End result is an increase of mosquitoes and dengue and other mosquito born diseaes.
Any over-kill method has tremendous turn around effects on flora and fauna including our birds and their breeding patterns.

Friday, April 10, 2020

Snake Age of India at Buddha’s time


Snake Age of India at Buddha’s time

Told to me by a very knowledgeable guy.

It was called “Ahi Yuga” in a particular state, in Buddha’s time.

The snake charmers are called "Ahi Kuntakas".

They used to consume snakes as a delicacy.
A virus transmitted by these snakes killed almost all in every household and those affected were kept isolated in closed doors to die in agony.
Then Buddha had asked his followers to stop eating flesh of following ten animals (I am not sure of the original 10).

1. Snakes
2. Monkeys
3. Pigs
4. Dogs
5. Domestic cats
6. Tigers
9. Lions
10. Elephant meat
?
11. Bats
12. Toads
13. Turtles
14. Tortoises

(Mind the list would have been longer and fish was not included).

Now I can see why Chinese, Koreans and most of the Chinese stock deliberately stopped Buddhism spreading in their territories.
Now the WHO is ably helping China to come out clean on “Wild Animal Trade” globally.

WHO and CHINA'S Failure

Reproduction

WHO and CHINA'S Failure

The WHO has not pushed China on early missteps.
When cases of a mysterious viral pneumonia first appeared in Wuhan in December, Chinese health officials silenced whistleblowers and repeatedly played down the severity of the outbreak.
Even as late as mid-January, as the virus spread beyond China’s borders, Chinese officials described it as “preventable and controllable” and said there was no evidence it could be transmitted between humans on a broad scale.
The WHO endorsed the government’s claims, saying in mid-January, for example, that human-to-human transmission had not been proved.
Critics say the organization’s repeated deference to Beijing exacerbated the spread of the disease. A group of international experts was not allowed to visit Wuhan until mid-February.
“They could have been more forceful, especially in the initial stages in the crisis when there was a cover-up and there was inaction,” said Yanzhong Huang, a global health expert specializing in China at Seton Hall University.
Huang noted that during the SARS epidemic in 2002 and 2003, which killed more than 700 people worldwide, the WHO pushed the Chinese government to be more transparent by publicly criticizing it for trying to conceal the outbreak.
At one point during the SARS epidemic, officials at hospitals in Beijing forced SARS patients into ambulances and drove them around to avoid their being seen by a visiting delegation of WHO experts, according to reports at the time.
WHO officials were slow to declare a public health emergency, critics say.
Even as the virus spread to more than half a dozen countries and forced China to place parts of Hubei province under lockdown in late January, the WHO was reluctant to declare it a global health emergency.
WHO officials said at the time that a committee that discussed the epidemic was divided on the question of whether to call it an emergency but concluded that it was too early. One official added that they weighed the impact such a declaration might have on the people of China.
After the United States announced a ban on most foreign citizens who had recently visited China, the WHO again seemed to show deference to Chinese officials, saying that travel restrictions were unnecessary. The group officially called the spread of the coronavirus a pandemic March 11.
Some experts argue that the institution’s delay in making such declarations deprived other countries of valuable time to prepare hospitals for an influx of patients.
“It reinforced the reluctance to take early strong measures before the catastrophe had actually landed on other shores,” said François Godement, senior adviser for Asia at Institut Montaigne, a nonprofit group in Paris. “The WHO’s tardiness or reluctance to call out the problem in full helped those who wanted to delay difficult decisions."
The WHO defended its actions, saying Wednesday that it had “alerted member states to the significant risks and consequences of COVID-19 and provided them with a continuous flow of information” ever since Chinese officials first reported the outbreak Dec. 31.
Guterres of the United Nations said, “It is possible that the same facts have had different readings by different entities.” He added in his statement: “Once we have finally turned the page on this epidemic, there must be a time to look back fully to understand how such a disease emerged and spread its devastation so quickly across the globe and how all those involved reacted to the crisis.”
China’s influence at the WHO is growing.
China’s leader, Xi Jinping, has made it a priority to strengthen Beijing’s clout at international institutions, including the WHO, seeing the U.S.-dominated global order as an impediment to his country’s rise as a superpower.
China contributes only a small fraction of the WHO’s $6 billion budget, while the United States is one of its main benefactors. But in recent years, Beijing has worked in other ways to expand its influence at the organization.
The government has lobbied the WHO to promote traditional Chinese medicine, which Xi has worked to harness as a source of national pride and deployed as a soft-power tool in developing countries, despite skepticism from some scientists about its effectiveness.
Last year, the WHO offered an endorsement of traditional Chinese medicine, including it in its influential medical compendium. The move was roundly criticized by animal welfare activists, who argued that it could contribute to a surge in illegal trafficking of wildlife whose parts are used in Chinese remedies.
China has sought to promote traditional Chinese medicine in the treatment of symptoms of the coronavirus both at home and abroad. Last month, the WHO was criticized after it removed a warning against taking traditional herbal remedies to treat the coronavirus from its websites in mainland China.
China’s role at the WHO will probably continue to grow in the coming years, especially if Western governments retreat from the organization, as Trump has threatened.
“This is part of China’s efforts to more actively engage in international institutions,” said Huang, the global health expert. “It will not please every country or every actor, but it’s going to affect the agenda of the WHO.”
This article originally appeared in The New York Times.

Thursday, April 9, 2020

Tuberculosis and BCG vaccination.


Tuberculosis and BCG vaccination.

My advice as a pathologist is that the TB vaccination (BCG) should be given at birth.

Furthermore, Mantoux test should be done before adolescent are vaccinated.

There were only two in our class (I was one and the other was Donald, Jaffna Tamil, my best friend) who were Mantoux negative out of over 50).

Only two of us got the BCG vaccination.


In other word 95% were exposed to TB as a Child (they should not be vaccinated to avoid reactivation of OLD TB).

This is true in India and Africa.

Then there is also Atypical or Anonymous Tuberculosis (PHD thesis of one of my teachers was not validated by the crooked supervising committee.in Peradeniya, fearing one may not get a chance to go abroad for higher studies).

Local degrees were considered inferior.
 
So annoyed my teacher gave up local research and ended up in Australia as a GP.

He had five children and all of them are doing well in many fields abroad.

So I decided to do my research in this country well past 50 yeas (my thesis) and part of the good quality data, I never gave to the University but used as my base for three books published at Amazon.)

By the way, I used five times the university contribution from my own pocket.
The money allocated was meager.

Coming to TB vaccination (polybacterial and polyvalent) as a whole there are lot of antigenic particles that activate lymphocytes and later taken up by the macrophages for intracellular digestion.

What it signals is that the macrophage has a nonspcific receptor on its surface to bind coated Coronavirus (not RNA particles).

One should identify this receptor in any new protocol.

Wednesday, April 8, 2020

Good, Bad and The Ugly

Good, Bad and The Ugly

The Coronavirus has good and the bad of us in one go.

Good think about it is, that we eat what we have not what we wished to have eaten.

For me all the collections of chocolates are over.

The Fruit and Nut ice cream I finished a month earlier.

Stopped alcohol totally due to the Tax Imposition by previous government.

Previous government lost due to this single tragedy.

This government will lose due to banning foreign alcohol and increase in illegal alcohol production and price.

Also they did not lower the price of alcohol and the price of Petrol and Diesel that plummeted due to Saudi action on Russians was a non event for us.

That low price is completely put under the carpet for now.

I have few friends who will definitely vote against who love alcohol as a way of life.

My advice for them to drink “Dasa-Mula-Aristaya” our high priests consume before a sermon and its alcohol content is over Vodka by many a mile.

I am currently preparing a list of 10 locally available (some may have to be imported like “Weniwel”) medicinal plants to be added to “Dasa-Mula-Aristaya” as our export quality local production with the help of “Siddha Lepa Veda Mahattaya” of old.

Bad things are the local “Paraya” dogs are hovering all over looking for food in desperation.

We do not have any food left to feed them like sprats and dry fish!

It was not my gut feeling, not to have another dog after our loving one's demise.

But I continued to feed the “Paraya Dogs” in plenty but never allowed them to follow me to home.

If I did NOW is the time for me to have a heart attack.

Now they call the “Politicians Paraya” after not having got a payment or have to pay the “Give Away Money” in installments over two years with six months grace period.

As for the birds including lovely parrots and Ceylon Oriole come daily to feed on mulberry (Ambul Ambili- found the Sinhala name while searching for medicinal plants) fruits and the “Honey Birds” feed on the three flowering plants.

Magpie and Bullbul started devouring and gorging on the guppy fish in style, I moved them to the big fish tank in panic state.

Now all the water lilies have large leaves giving them cover from the predators.

A Bullbul pair made a nest over the pond and I made it sure I spray enough water over them while watering the tall bamboo trees covering the edge.

They decided not to lay eggs.

As for the rooftop garden there are no restrictions and they can feed and drink and make even nests, if they so desire.

The black bees have a colony and they feed on the lily flower pollen.

It takes solid three hours for me to water the plants and fill the containers (drying up in hot sun).

On an economy note, I decided to feed the fish only twice a week since my last packet of fish food is going down fast.
They have to survive on diatoms and algae and the population control is on the card and birds doing it in style.
The bat who decided to make a home did not find a partner and never came back with Coronavirus as a treat for the New Year.

My Thoughts on Coronavirus


My Thoughts on Coronavirus


Coronavirus coated particles are ONLY 120 nanometers.

It behaves like a enterovirus with hepatic phase before the respiratory complications (pneumonia)

Its asymmetric SINGLE RNA particles are much smaller and can assemble the infectivity and virulence even after one year (my belief) lay off.

In EVOLUTION RNA lasted pretty obstacles much better than DNA (double strand).

This EPIDEMIC is clearly lasts at lest two years.

1918-1919 Flu is the tell tale evidence but this is much better oriented to cause HAVOC.

I am not paranoid in this assessment.

Facemask has no place (smal viral RNA partcles can penetrate) but HAND WASHING several times a day is VITAL with or without soap.

Clean water is OUR current GOD.

Do not pollute with CHEMICAL HAZARDS (what they are spraying liberally now).

Saturday, April 4, 2020

A Single Virus and a Humble Animal Send the Whole World into Lockdown

Reproduction

The author was our president for two terms, who retired gracefully from politics.

A Single Virus and a Humble Animal Send the Whole World into Lockdown



By Chandrika Bandaranaike Kumaratunga
The world has been attacked by the most widely spread pandemic the world has ever experienced.  It has had seismic effects on the entire world – almost no country has been spared from its terrifying repercussions.
We humans prided ourselves that we had conquered Mother Nature.  We indiscriminately destroyed her bountiful forests, thereby destroying large numbers of wild life or creating unnatural conditions in which humans were called upon to live in close proximity with wild animals.  We heartlessly polluted her rivers. Lakes and seas and the air that we breathe in the name of increased GDP and economic growth rates, regardless of the long-term dangers of all living beings.
We now find that we are knocked senseless by one single virus carried to us by a humble bat.  The entire world has been forced into lock-down.  We are only beginning to comprehend the possible outcome of this global viral attack on the national and global economy.  Not only would we have to re-think the whole paradigm of development, our concept of life and how we live it will change radically.
National Governments are acting individually in heroic attempts to contain the spread of the disease.  International and regional organisations too have gone into lockdown mode themselves, due perhaps to the unpreparedness of these organisaions for the present situation.  Nobody seems to have imagined that the shock and awe attack by a single virus could create such havoc, at such an unimaginable scale as the Corona Covid-19 virus has done.
The response of global and regional organisations has disappointed a lot of us, who believe in the necessity and power of international organisations to deal with issues that affect many or all countries of the world, by their very composition and objectives which we believe are to bring the world together in joint action, in times of peace and also when urgent action is required when emergencies arise.  We are disappointed that the global and regional organisations appear to be inept to deal with the present emergency.
It is evident that the first thing to do in this emergency is to control the spread of the disease, while medically caring for those who are infected by it.  I would call this, dealing with the result of a deep and serious problem.
It would be most constructive to study the origins of the problem – how and from where the present Covid virus came to infect the human being.
Innumerable theses are being expounded presently about the origins ohe virus, the manner in which it spread, and so on.  Even conspiracy theories are being circulated widely through social media.  At this time it is essential to base our understanding and explanations on established scientific facts and not various bits of somebody’s vivid imagination.  We must inquire if the theories that are put forward to us have any solid scientific basis.  If not, believing all this nonsense could lead to diverse political and human conflicts.
Serious research has demonstrated that as far back as 13 years ago in 2007, academics have raised alarm with regard to “wet markets” and the indiscriminate consumption of wild life in China, the Far East and countries in South America, as well as in many other countries worldwide.  Several papers by Chinese academic Cheng and others in their Paper written in 2007, gives a clear warning :
"Coronaviruses are well known to undergo genetic recombination, which may lead to new genotypes and outbreaks. The presence of a large reservoir of SARS-CoV-like viruses in horseshoe bats, together with the culture of eating exotic mammals in southern China, is a time bomb. The possibility of the reemergence of SARS and other novel viruses from animals or laboratories and therefore the need for preparedness should not be ignored."
Then Yi Fan and others in a Paper published in 2019 give an ominous prediction:
"Thus, it is highly likely that future SARS- or MERS-like coronavirus out​breaks will originate from bats, and there is an increased probability that this will occur in China."
Scientists at the forefront of infectious disease surveillance and research and epidemiologists have been warning their Governments and the whole world about the imminent danger of consuming wild animals as food.  It is unforgivable that the relative Governments, as well as international organisations, took no notice of this.
We are aware that the illegal international wildlife trade and the wet market trade of wild animals earns the Chinese economy as much as US$ 74 Billion per annum.  The short and medium term cost to Governments by the Covid 19 pandemic will likely be much more than fifty-fold of that value.
Didier Sicard, a French specialist of infectious diseases, working at the Institut Pasteur in Laos has noted that bats have harboured the Corona virus in their bodies since millions of years and can, in certain circumstances, disperse them to humans and other animals.  The destruction of virgin forests in Laos, for instance, has rendered it possible for bats, which normally live deep in the forests and caves, to begin to live close to human habitation and hence open up the flood-gates to spread the infection.  In this epidemic we know how dangerous contact could prove for the spread of the virus.
We are aware that the starting point of this pandemic is a public “wet market” in Wuhan where wild animals such as serpents, bats and others are kept crowded in cane baskets.  These animals are bought and consumed as delicacies.  This market is known to be crowded with animals and human beings and is not famous for its levels of cleanliness.  Hence, infected animals would have infected other animals, which in turn would have infected people.
In a seminal article written by Tara Schlegel,* she expresses surprise that our countries seem to be mainly interested in producing vaccines, treatments and re-animation which is admittedly the immediate requirement, but shows little or no interest with regard to the cause and the origins of the virus.  The problem is further compounded by our knowledge that wild animals are effectively at the origin of a large number of epidemics since the beginning of time – the Plague, HIV, bird flu, Ebola are some recent examples.  
It is said that bats carry some 30-odd corona-type viruses.  
Snakes of all types live in the same caves and forests inhabited by bats.  When bats die in their caves they are eaten by serpents, which thereby become infected by the virus.  It is also thoughts that other animals/insects such as ants could be infected.  All this makes it evident that extensive research needs to be undertaken to study the entire chain of contamination caused by the bats.
The study of the relationship between the Covid-9 carrying bats and their contamination of serpents, in addition to ants and other animals which live in close proximity of the serpents, and how they could infect humans becomes essential if we are to understand how humans contract the virus and how we could control the spread of it.
The accelerated destruction of forest cover in Indo-China and China could be a certain cause of bringing human habitation unnaturally close to that of wild animals and thereby promoting the propagation of various diseases, including the Covid Virus.

URGENT GLOBAL ACTION REQUIRED
1.    Global action appears essential for joint programmes of research to study the origins and the chain of transmission of the virus, about which I have given details above.  This implies in-depth study of the animals which transmit this virus.  It would also imply the study of other animals such as rats, which are known to transmit the bacteria that causes plague.
*Tara Schlegel, Radio France.
2.    International action to bring laws to forbid national and international trade in wild animals and the total ban of “wet markets” in every country of the world.  It may become necessary to create International/Regional institutions to monitor the implementation of these laws, with independent inspectors to survey the implementation at local level.
3.    To promote close and effective co-operation between Governments under the aegis of International Organisations such as the UNO and regional  organizations and the WHO, for the development of medical treatment, preventive vaccines, etc. to fight the covid-19 virus.  The WHO will have to re-structure itself to meet the present emergency, as well as other similar health emergencies which seem imminent in our world today.
To achieve this, it is proposed that an international meeting of a selected number of former and present leaders of Government, together with experts, be summoned without delay, with the objective of formulating policies and a programme of action.  This process could be co-ordinated and/or led by the UNO.